Normally only if the display has its own controller, and you talk to it via SPI, i2c, or an 8 or 16 bit interface.
But those methods are slower and if you're doing a higher resolution user interface, the RGB interface lets you drive stuff like an 800x480 display at well over 60 fps.
The IPS version of this is my current favorite: https://www.aliexpress.us/item/3256804766379290.html