Previously significant, geographical constraints matter less in today’s globally connected world. Arguably, becoming more important in relative terms are mindset, creative and strategic thinking, willingness to work both smart and hard—and those would be in abundance.
Admittedly, Hong Kong benefitted a lot from being the convenient middle ground where major deals between entities in mainland China and other countries could happen. However, it can also be argued that meeting in person to shake hands might not remain a given going forward.
But you still need something to leverage. Distance from population centers matters, trading routes matter, topography matters immensely as well.
Britain rose in conjunction with Trans-Atlantic trade. And so did Japan with Trans-Pacific trade and the development of the American West coast.
HK is an I/O hub for one of the largest economies in the world, it doesn't get much better.
An hypothetical Neo-HK somewhere would have to forcefully re-route the world's economy to have a chance at getting the same standing.