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Has someone that thought they were taking LSD ever turned into a permanent schizophrenic zombie or in a mental institution, or is it all urban legend. If someone that didn't know they were predisposed to mental illness, is it applicable to dismiss their experience in order to maintain how safe LSD is?

If any of this is true, are there any sources aside from "my friend's friend's brother took too much and now he is....", and what is the scientific explanation and do we know enough about the mind at all?

I feel like LSD has a lot of contradictory information out there, and the proponents feel the need to hand waive concerns away because it is 'completely harmless and leaves your system in 10 hours'. But when nobody knows what they're actually getting because it doesn't exist in a legal framework, then it muddies the whole experience.

People say certain doses can't do more effect than lower doses after a certain threshold. It seems like the same people say "omg man 1000ug you are going to fry your brain!"

What is the truth? If it "just" had an FDA warning like "people with a family history of schizophrenia should not take it", that would be wildly better than what we have today.

Please no explanation about shrooms. Just LSD the 'research chems' distributed as LSD.




"Has someone that thought they were taking LSD ever turned into a permanent schizophrenic zombie or in a mental institution, or is it all urban legend."

Tangential, and not an answer to your question, but if you're like me, you will be fascinated to learn that there is a drug (MPPP, synthetic opiate) that if cooked incorrectly yields "MPTP"[1] which will give you Parkinsons. As in, forever. You take this drug (at any age) and then you have Parkinsons for the rest of your life.

[1] https://en.wikipedia.org/wiki/MPTP


so therefore it stands to reason that other substances can exist that rewrite your mind to make you ineffective at other behaviors


I mean, not really.

1. There is one substance that rewrites your mind.

2. There is more than one substance that rewrites your mind.

Are very different postulates.


1 opens the existence of 2 as possible


When I looked up into illegal drugs, I found it very difficult to find reliable data.

On one hand you have anti-drug people, usually backed by the authorities. Listen to them and all drugs will make your body rot, give you hallucinations like datura, and for some reason cause complete addiction after a single dose.

Drug users on the other hand will tell you that it not as bad as alcohol/tobacco/coffee/... that concerns are unfounded, that police is the only risk, etc...

The truth is almost impossible to find. Even peer reviewed research is lacking. I guess there are several reasons for that. Availability of controlled substances. Ethical concerns regarding experimentation. Issues with neutrality.

Now from what I gathered about LSD (and psychedelics in general): these are very random. If you take a reasonable dose, you are most likely going to have a nice, fun trip and nothing more. But it can also fuck you up for years, or maybe bring significant improvement in your life. High doses increase the chance of extreme effects and nasty bad trips, but it shouldn't kill you unless you are dealing with industrial quantities. The substance itself is not addictive, but the social context may be. The big problem is that there is no way to tell how it will go for you. There are ways to improve your chances, but it will always be random.

As for fake LSD, there are cheap reagent tests for that. They are not 100% reliable but that's better than nothing. You can also send your sample anonymously to a lab that will do a much more accurate GC/MS analysis for you.


> Drug users on the other hand will tell you that it not as bad as alcohol/tobacco/coffee/... that concerns are unfounded, that police is the only risk, etc...

Sure, some ("plenty", in absolute numbers) will tell you this, but I don't recall being in many forums where that attitude doesn't get significant pushback (as opposed to the anti-drug community). The modern "pro drug" community has a fairly significant culture of safety within it, unlike back in the sixties.

> The truth is almost impossible to find.

There is plentiful anecdotal evidence online. Any clinical evidence, if they ever get around to doing it in any significant volumes, will be utterly miniscule (and I highly doubt more trustworthy, considering what you're working with, and the size of the tests that will be done) to the massive volume of trip reports and Q&A available online, much from people who know very well what they're talking about, not unlike enthusiasts in any domain.

> Now from what I gathered about LSD (and psychedelics in general): these are very random.

Depends on one's definition of random.

> If you take a reasonable dose, you are most likely going to have a nice, fun trip and nothing more.

Effects vary by dose of course, but I've seen little anecdotal evidence that suggest high doses have a different outcome, and plenty that suggests the opposite.

> But it can also fuck you up for years, or maybe bring significant improvement in your life.

See: https://rationalwiki.org/wiki/Balance_fallacy

> The big problem is that there is no way to tell how it will go for you. There are ways to improve your chances, but it will always be random.

I believe this to be true, but don't forget the fallacy noted above.

That said, these things are not toys - extreme caution is warranted.


Permanent schizophrenic zombie, maybe a bit extreme, but severe and traumatic long-lasting psychological damage is a not-uncommon phenomena.

I had a fling with psychedelics in my teens, and everything was great until the one time it wasn't. I was taking psychedelics pretty much every weekend, and by my count have tried over a dozen of them.

Had an experience with LSD which completely shook me to my core and gave me such severe PTSD and trauma that every night I started to have massive panic attacks and needed medical help. My entire worldview and perception of reality was shattered, I wasn't able to "anchor" myself anymore and it all felt like a sham. I was completely dissociated. I also got HPPD: to this day, everything has a sharpened oil-painting type texture to it that increases based on my anxiety level, and I'm sensitive to visual + aural stimuli (loud, brightly-colored places are unpleasant). If I get too anxious, I start to dissociate.

It took ~2 years for the PTSD to subside for the most part, but still if I am under a lot of stress I am liable to have a panic attack and get flashbacks and need to go find somewhere quiet to sit somewhere alone to try to work through it.

LSD being the particular substance has nothing to do with it, in my opinion. I was young, dumb, reckless, and played with fire then got burned. It could have happened with any of the other dozen psychedelics I took, but it just so happened to be LSD the one time that it did.

But I want to add, that while giving me the most nightmarish, traumatizing experience of my life, the best/most positively-profound experience has also been on the same substance. I grew up in a pretty abusive household and didn't do well forming relationships growing up, and had a lot of anger and resentment in my worldview. After taking psychedelics (LSD, 2C-B, Shrooms) and MDMA with the right group of people a few times, my entire perspective shifted. For the first time in my life, it felt like I understand how it felt to be loved, and what "love" was, and how we're "all in this together" so we may as well be good to each other while we're here.

It's been a long time since I've touched any of that stuff and I'm not sure I ever will again, but I don't think it's inherently bad or good. Psychedelics are like knives, they're neutral - can be used as a tool or cut the hell out of you if you're reckless.

---

Footnote: For context, this was probably due to life circumstances/psyche at the time. I was in a relationship with a pretty toxic partner, and my mental state wasn't the greatest. In hindsight, it seems like I was almost begging for a "slap in the face" if you will.


If you don't mind me asking (and this is clearly a sensitive topic so feel free not to reply): What do you mean by PTSD and flashbacks? As in, was the trip so bad that remembering it creates anxiety, or are you reliving unrelated traumatic memories that weren't an issue to live with before using the drug?


It literally feels as if I'm being transported back to that same night, starting to relive it all over again. It's entirely illogical but if you knew what happened it might make more sense (happy to elaborate here and give a brief description of what happened/why it messed me up so bad, I'm perfectly okay to talk about it now).


I'd be interested to hear your story. I've never used psychedelic drugs, but I find their effects fascinating.


I took 300ug of LSD recklessly on a particularly bad day for me, in a particularly uncomfortable setting.

Well, that night went bad. Really, really, life-alteringly bad. For the first time, I had a bad trip. And not like, some mildly uncomfortable thoughts. I got a bad feeling in my stomach from the moment I dosed, and I knew something was going to be different this time.

As I started to come up, the bad feeling and a dark presence grew, and I pulled out my phone. I started a timer, and I watched as the time slowed to a point where it completely stopped. I started looping, I would get up off the couch, walk a few feet, and be teleported back. Over and over.

I realized that I had gotten so high, that time was no longer moving. And if time was not moving, I could maybe never come down. I was stuck here forever. And then the hellish nightmare started.

I felt like I was losing control of myself, like something else was trying to take over, and whoever won the battle, that is the consciousness that would exist. The more I fought, the more painful things got. Pain the likes of which I no one can physically imagine.

Went upstairs and laid down in my bed, began going out of body. I started dying over and over in unimaginable ways in my head, trapped in loops. Pain beyond anything I've ever felt in reality, there was no limit. It was tied to my breath, I realized that it had been so long since I had breathed, I kept forgetting who I was and what was going on, and then I would catch a slight glimpse and remember and fight so hard to take another breath. And there was so much pain in fighting to "survive" and hold on to who I was.

Eventually, the pain/struggle became too much, and I "gave in" and said "okay, I give up, you win, I can't take it anymore, I'd rather die." And that's when it's stopped. There appeared this giant shape of light/energy that was every color at once, and colors we don't have words for, and it "touched me" (could have been me moving towards it, or it towards me, there wasn't really a concept of this).

When it "touched" me, what it "showed" me was something I later learned is called an "Ouroboros", the snake eating it's tail. It showed me what "infinity" really meant, and that was too much to handle and shattered my psyche.

In that moment my body/mind/soul felt like it was obliterated to pieces by some energy beam in the most excruciating, searing pain, and I woke up in my bed having just pissed myself.

It took a long time to piece myself back together after that one.

---

There are a lot of details I've omitted for brevity's sake, but this captures the gist of it.

The majority of my trauma has to do with anything related to loops: think Nietzsche's Eternal Return, general time-loops, fear of time-stopping, etc.

When I have panic attacks I have to stop myself from starting a stopwatch on my phone to make sure time is still moving because it'll cause a feedback loop and ratchet-up the panic, causing the time-dilation to increase in a vicious cycle.


Holy. That sounds intense, to say the least. A part of me likes to experience this, even though you made it abundantly clear, that it did not have a positive impact on your life.


"ego death" is a common aspect of acid trips and the experience seems to come down to your willingness to relinquish control. this reads like what was described. if you were to look up that term you'll see others that will feature similar features - with or without pain, with or without worry.

not having a reliable way to know exactly what you took can amplify the anxiety, when your brain starts filling up with seratonin and whites everything out just like people on their deathbeds report, are you supposed to let go? when your sense of self has been obliterated and the next moment you are in the body of another mammal lost and confused in the forest for an entire lifetime before being transported back into your body and only a minute has gone by - but your trip is to last another 9 hours, should you fight it? Distinct neural networks in your mind that never communicate are now connected, vestigial components of the mind are now being expressed, are you being replaced in a firmware dump and flash?

a lot of people have a friend with them to guide them through an acid trip because trips can be steered with sounds and words, simple chimes, melodies.

would it have helped? very hard to say. but as the author wrote, the bad day and uncomfortable setting did not help. It is similar to a dream state (just radically more intense), where the things on your mind and also happening around you can affect the direction of your dreams.


Yeah, I think it entirely had to do with my inability to relinquish control and "just let go". Although in this context, that was literally what felt like the fight to survive, instead of "being chill". Ego death commonly is either the most horrendous or most nirvanic thing depending on how readily someone gives in.

> when your sense of self has been obliterated and the next moment you are in the body of another mammal lost and confused in the forest for an entire lifetime before being transported back into your body and only a minute has gone by - but your trip is to last another 9 hours, should you fight it?

There was a lot of this, during that out-of-body-period. I existed in multiple places/points in time at once as different people of various ages/genders/nationalities and then occasionally as animals, and lived entire simultaneous lifetimes. At one "time", in places + times A, B, C, D as different living things. Really does a number on your sense of self for a bit, heh.


and that had never happened to you in your other trips?


No, was really strange, I was pretty experienced by then too. Was never the same after.


Did you take 300ug before?

Sorry for the questions, we can talk about it somewhere else, just add an email or protonmail account to your hackernews account I'll mail you there


Did you try LSD after that time in your teens?

I think it is a bit too reductive to say they're neutral, just yet, but I am willing to say they can be used responsibly if the right information actually existed - but like with any science I am open to changing that if the conclusions were found to be different. Again let's just stick with acid instead of all psychedelics.


I tried once or twice after that, both times it turned immediately into flashbacks and led to horrid experiences so I called it quits for good.

I had done it probably ~20-25 times by that point, along with a bunch of other stuff.

    LSD
    Mushrooms
    2C-B
    2C-C
    2C-I
    DMT
    4-AcO-DMT
    5-MeO-DMT
    5-MeO-MiPT
    DOM
There might be some others I've forgotten, it's been a long time.

> Again let's just stick with acid instead of all psychedelics.

What you won't find in academia or textbooks is that, at a high enough dose, all psychedelics feel the same. You reach a point where it's indistinguishable and the unique properties vanish. It's hard to describe if you don't have experience with a bunch of them, but there's this "peak psychedelic state" where they all sort of converge, which is what I only assume is the result of your serotonin receptors getting completely bombed/saturated.

Personally, I was much more of a fan of phenethylamine psychedelics (particularly the 2C series), they're more clear-headed and "light"/enjoyable. The time dilation from psychedelics makes the 12-16 hours from LSD feel like days, and by the end of it, generally the last 4-6 hours you just want to be finished with it already.

It's really difficult to make a blanket-statement like "can be used responsibly" about psychedelics, because it's a dice roll. No matter how cautious you are, there's always the possible that this time, things go sideways. Though most people (when I was in that scene as a teen) couldn't really empathize after my bad trip because they'd never had one, so it's a rare occurrence. Maybe I was psychologically predisposed, who knows.

But I do think that people stand to gain a lot from having a psychedelic experience in their life, and from having an experience taking MDMA and talking with someone they love.


> Though most people (when I was in that scene as a teen) couldn't really empathize after my bad trip because they'd never had one, so it's a rare occurrence.

Yeah this is another thing I've seen.

Online there are lots of stories of "bad trips", like this one.

In person its "what happened? I've never had a bad trip [so what's wrong with you]". It is very unscientific, and for the people that do empathize, it is very reductive to "bad trip". No discussion about PTSD. And then you can't talk to anybody else about it because they are illicit substances.


Just some relevant info I looked up after reading your post....

> Permanent schizophrenic zombie, maybe a bit extreme, but severe and traumatic long-lasting psychological damage is a not-uncommon phenomena.

https://english.stackexchange.com/questions/6124/does-not-un...

https://towardsdatascience.com/an-introduction-to-multivaria...

HOW PSYCHEDELICS REVEALS HOW LITTLE WE KNOW ABOUT ANYTHING - Jordan Peterson | London Real --> https://www.youtube.com/watch?v=UaY0H9DBokA

Jordan Peterson - The Mystery of DMT and Psilocybin --> https://www.youtube.com/watch?v=Gol5sPM073k

> LSD being the particular substance has nothing to do with it, in my opinion. I was young, dumb, reckless, and played with fire then got burned. It could have happened with any of the other dozen psychedelics I took, but it just so happened to be LSD the one time that it did.

https://en.wikipedia.org/wiki/Hallucinogen_persisting_percep...

I have a close friend who had the same experience with excessive use of marijuana, but my money would be on psychedelics being far more likely to produce the outcome you unfortunately experienced. He's much better today, but not entirely "ok".

> But I want to add, that while giving me the most nightmarish, traumatizing experience of my life, the best/most positively-profound experience has also been on the same substance. I grew up in a pretty abusive household and didn't do well forming relationships growing up, and had a lot of anger and resentment in my worldview. After taking psychedelics (LSD, 2C-B, Shrooms) and MDMA with the right group of people a few times, my entire perspective shifted. For the first time in my life, it felt like I understand how it felt to be loved, and what "love" was, and how we're "all in this together" so we may as well be good to each other while we're here.

This sounds rather similar to my friend's story.

Can Taking Ecstasy (MDMA) Once Damage Your Memory?

https://www.sciencedaily.com/releases/2008/10/081009072714.h...

According to Professor Laws from the University’s School of Psychology, taking the drug just once can damage memory. In a talk entitled "Can taking ecstasy once damage your memory?", he will reveal that ecstasy users show significantly impaired memory when compared to non-ecstasy users and that the amount of ecstasy consumed is largely irrelevant. Indeed, taking the drug even just once may cause significant short and long-term memory loss. Professor Laws findings are based on the largest analysis of memory data derived from 26 studies of 600 ecstasy users.

> (from your comment below) I took 300ug of LSD recklessly on a particularly bad day for me, in a particularly uncomfortable setting.

https://www.trippingly.net/lsd/2018/5/3/phases-of-an-lsd-tri...

Lots of details, plus dosage guide (25 ug and up) & typical experinces

https://www.reddit.com/r/LSD/comments/34acza/do_you_guys_bel...

imo 300ug is the point where you need to have some serious experience with tripping to be able to handle yourself. because if you're coming up, the acid is already circulating your bloodstream, and you get that horrible sinking sensation of thinking you've taken too much... you're in for a really bad time if you don't know how to control the trip.

I think it's difficult to say how big a dose really is until you've had a bad trip on it. only then can you see how insidious everything can get and as such just how intense 300ug can be. the reason people say not to start on doses like that is so they will AVOID those horrible experiences. so yeah, 300ug is a large dose, just because if shit goes wrong on it then you're fucked.


> Has someone that thought they were taking LSD ever turned into a permanent schizophrenic zombie or in a mental institution, or is it all urban legend. If someone that didn't know they were predisposed to mental illness, is it applicable to dismiss their experience in order to maintain how safe LSD is?

My good friend took "something" once (hard to tell what the dealer is selling you) and ended up in a mental institution, and is now in fact officially mentally disabled and on drugs for life. The drugs keep him stable enough that he's able to work, although he's still just a shadow of his former self.


What was he expecting to have taken?


Head over to the phantasytour forums, place is full of acid casualties.


> But when nobody knows what they're actually getting because it doesn't exist in a legal framework, then it muddies the whole experience.

Trust (knowing the chemist directly, indirectly, ...) in specific individuals > a largely unknown (but known to be imperfect) system, for many people anyways. Obviously this isn't practical for the not well connected, but it's all we got for now.

But as for your question, I've seen little to suggest it's anything more than war on drugs propaganda and hearsay.

https://en.m.wikipedia.org/wiki/Reefer_Madness

https://en.m.wikipedia.org/wiki/Chinese_whispers


yes this is my current predilection, but I can also concede that there are limitations in getting the truth of the matter.

even in this very thread there is someone that has been in the mental hospitals and seen problems "with their own two eyes", but is unwilling to name names as part of a code to remove any social/legal/professional consequence for themselves or the "crazy" people there


Dipping ones toes in the water is always an option, but I heard a rumour psilocybin is the safer route, due to less likelihood of illegitimate product.

If you live in a big enough city, there should be meetup groups where you could meet some people and have long discussions.

Is your interest only curiosity, or is it medical related? Sorry, on mobile and pressed for time so can't scroll through the thread..


This entertaining article lists what happened to the early LSD researchers: https://slatestarcodex.com/2016/04/28/why-were-early-psyched...


entertaining, the comments are a good addendum but are just as speculative. maybe there just isn't good information, its just more of the contradictory information.

"lasting permanent changes, obviously"

"I’ve personally seen several people experience total amnesia after tripping on high doses." No further information.

"Not lasting permanent changes"

what.

Names, sources, medical records, news reports, court cases, there has got to be something out there!


The answer to this is really easy. Go to any mental institution and get to know the patients. An institution where they are allowed out, but are still in an enclosed area. A majority of the patients will have had some sort of heavy drug use in their past. Sure, whats causation and whats correlation, but its pretty clear that drugs cause mental breaks.

How do I know this?

I have mental illness in my family and have spent considerable amounts of time at those facilities.


> Sure, whats causation and whats correlation, but its pretty clear

What? How is it clear? As you wrote yourself, correlation is not causation.


I was just protecting against the inevitable counter argument. The proof is what I have seen with my own two eyes


That's unfortunate. Yes, I think it is clear too, but to so many it isn't that I have to figure out where is the truth? What circumstances cause what? Is it worthwhile to really avoid all psychonauts given the path they are on? For the ones with positive experiences on the total other side of the spectrum that take them into the spiritual mumbo jumbo, is this worth listening to? Is there a functional difference between the path the microdosers are taking and the ones that use 1000ug occassionally (ie. after smart people's 2.5 year stint at Google are they all on the path to a mental hospital?)

So many questions.

Where is the medical journal that says your conclusion "vast majority of mental health patients have a self-reported history of drug use of these specific drugs". I guess it can't exist because its crazy people self reporting a variety of substances that even the user would have no idea what was actually given to them.




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