Usually I do stop a few times, but recently decided to just power through it. Last time I didn't even realize how much time had passed until the gas light came on.
6-8 hours is about what I can do on a plane without getting up too so it's not too bad for me. Truckers do it all the time too so it's not that rare.
Edit:
If electric can get to 400+ miles (already there almost) I'll be sold. That's enough for me to do the entire trip with only adding an extra stop if I drove nonstop. When I calculated with the 200-300 mile range a year or so ago it would have been too much waiting around for a charge.
You don't have to concentrate when flying. What's the legal limit in the US for truck drivers without a break? In the EU its 4.5 hours https://www.gov.uk/drivers-hours/eu-rules
I fly when it's cheaper (not counting my time). If I can find flights ~100-150/rt then that's a possible solution, but adding a rental car + parking at airport often makes it just cheaper to drive. And besides, I enjoy it.
Per DOT rules, truckers here are allowed up to 8 hours non stop, with a mandatory 30 minute break if they go over. They can drive up to 11 hours in a 14 hour window.
I think most people would need to stop a couple of times on route. I doubt EVs will ever be suitable for you.