F.lux is great but the root of the problem is the type of backlight that monitors use. A hardware company ought to come out that produces a decent monitor with multiple backlight bulbs.

I mean, look at the difference in abrasiveness of spectrum between these bulb technologies:

http://housecraft.ca/wp-content/uploads/2012/09/spectral_res...

Tinting the color using F.lux is helpful but doesn't supplant the boon that a proper ergonomic monitor would for eye and circadian rhythm health.